Antioxidant Outcomes of L-arginine on Monosodium Glutamate-induced Oxidative Stress in Rats’ Testes


  • Anthony Cemaluk C. Egbuonu Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria


Superoxide dismutase, malondialdehyde, reduced glutathione, catalase


Oxidative stress was implicated in monosodium glutamate-related adversity in male reproductive organs. This study examined the possible antioxidant outcomes of L-arginine on oxidative stress induced by monosodium glutamate burden (8000 mg/kg of body weight) in rats’ testes after oral intubation for 28 days. Exposure to monosodium glutamate significantly (p < 0.05) increased malondialdehyde (3.84±0.34 mg/dl) level but diminished the level of reduced glutathione (9.60 ± 0.28 mg/dL), catalase (5.51 ± 0.35 IU/L) and superoxide dismutase (1.74 ± 0.20 IU/L) in the rats’ testes homogenate compared to control and other groups. L-arginine treatment alone or l-arginine co-treatments with monosodium glutamate significantly (p < 0.05) decreased the level of malondialdehyde but increased that of reduced glutathione, catalase and superoxide dismutase in the rats’ testes compared to control and monosodium glutamate treated groups. Thus, the oxidant effects induced by monosodium glutamate at a dose of 8000 mg/kg in the rats’ testes were significantly mitigated by L-arginine. This portends the antioxidative role of L-arginine in oxidative stress related testes dysfunctions by probable deregulation in malondialdehyde but up-regulation in reduced glutathione, catalase, and superoxide dismutase expression and functions.


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How to Cite

Egbuonu, A. C. C. (2022). Antioxidant Outcomes of L-arginine on Monosodium Glutamate-induced Oxidative Stress in Rats’ Testes. Nigerian Journal of Biochemistry and Molecular Biology, 37(2), 128–132. Retrieved from



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