Chrysin Attenuates Osteoporosis-induced Hyperlipidemia and Oxidative Damage in Ovariectomized Rats

Authors

  • Sanusi B. Mada Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author https://orcid.org/0000-0002-2110-5181
  • Muhammad A. Saliu Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author https://orcid.org/0000-0002-9739-8830
  • Sadiyat O. Ibrahim Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author https://orcid.org/0000-0003-3505-5223
  • Muawiya M. Abarshi Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author
  • Auwalu Garba Department of Biochemistry Author
  • Nasiru A. Garba Department of Biochemistry, Federal University Gusau, Nigeria Author
  • Abubakar Shuaibu Department of Biochemistry Author
  • Ahmad B. Hamza Department of Biochemistry Author
  • Aminu M. Jabbi Department of Biological Sciences, Federal University Gusau, Nigeria Author

Keywords:

Ovariectomy, Osteoporosis, Hyperlipidemia, Oxidative damage, Chrysin

Abstract

Cardiovascular disease and postmenopausal osteoporosis are age-related diseases with high morbidity and mortality across the globe, especially in the elderly women. This study investigates the potential effects of chrysin (CHR) in osteoporosis-induced hyperlipidemia and oxidative liver damage in ovariectomized rats. Twenty-five female Wistar rats were used; 20 rats were ovariectomized (OVX) while 5 rats were sham-operated. The experimental rats were treated daily for a period of six weeks. CHR treatment alleviated body weight gain (p<0.01) in OVX rats. In addition, CHR significantly (p<0.05) reduced total cholesterol, triacylglycerol and low-density lipoprotein with a simultaneous increase in high-density lipoprotein levels in OVX rats in a dose-dependent manner in comparison to untreated OVX rats. Moreover, treatment of OVX rats with CHR significantly (p<0.05) reduced malondialdehyde level and improved reduced glutathione level, superoxide-dismutase and catalase activities. Furthermore, treatment of OVX rats with CHR significantly (p<0.01) suppressed alanine-aminotransferase and aspartate-aminotransferase activities in liver tissue compared to the untreated OVX rats. Conversely, treatment of OVX rats with CHR significantly (p<0.05) attenuated reduction in femur bone calcium, phosphorus, magnesium and zinc contents altered by ovariectomy compared with untreated OVX rats. This study demonstrated that CHR reduced symptoms of osteoporosis-induced hyperlipidemia and oxidative damage in OVX rats. Our data suggest that CHR, a natural antioxidant, may potentially protect against postmenopausal osteoporosis linked to cardiovascular disease.

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Author Biography

  • Muhammad A. Saliu, Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria

     

     

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Published

2023-07-23

How to Cite

Chrysin Attenuates Osteoporosis-induced Hyperlipidemia and Oxidative Damage in Ovariectomized Rats. (2023). Nigerian Journal of Biochemistry and Molecular Biology, 38(2), 83-93. https://www.nsbmb.org.ng/journals/index.php/njbmb/article/view/188

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