Chrysin Attenuates Osteoporosis-induced Hyperlipidemia and Oxidative Damage in Ovariectomized Rats
Keywords:
Ovariectomy, Osteoporosis, Hyperlipidemia, Oxidative damage, ChrysinAbstract
Cardiovascular disease and postmenopausal osteoporosis are age-related diseases with high morbidity and mortality across the globe, especially in the elderly women. This study investigates the potential effects of chrysin (CHR) in osteoporosis-induced hyperlipidemia and oxidative liver damage in ovariectomized rats. Twenty-five female Wistar rats were used; 20 rats were ovariectomized (OVX) while 5 rats were sham-operated. The experimental rats were treated daily for a period of six weeks. CHR treatment alleviated body weight gain (p<0.01) in OVX rats. In addition, CHR significantly (p<0.05) reduced total cholesterol, triacylglycerol and low-density lipoprotein with a simultaneous increase in high-density lipoprotein levels in OVX rats in a dose-dependent manner in comparison to untreated OVX rats. Moreover, treatment of OVX rats with CHR significantly (p<0.05) reduced malondialdehyde level and improved reduced glutathione level, superoxide-dismutase and catalase activities. Furthermore, treatment of OVX rats with CHR significantly (p<0.01) suppressed alanine-aminotransferase and aspartate-aminotransferase activities in liver tissue compared to the untreated OVX rats. Conversely, treatment of OVX rats with CHR significantly (p<0.05) attenuated reduction in femur bone calcium, phosphorus, magnesium and zinc contents altered by ovariectomy compared with untreated OVX rats. This study demonstrated that CHR reduced symptoms of osteoporosis-induced hyperlipidemia and oxidative damage in OVX rats. Our data suggest that CHR, a natural antioxidant, may potentially protect against postmenopausal osteoporosis linked to cardiovascular disease.
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Copyright (c) 2023 Dr Sanusi Bello Mada, Muhammad Auwal Saliu, Sadiyat Oyiza Ibrahim, Professor Muawiya Musa Abarshi, Dr. Auwalu Garba, Professor Nasiru Anka Garba, Abubakar Shuaibu, Ahmad Balarabe Hamza, Dr. Aminu Muhammad Jabbi
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