Hypoglycaemic and Hypolipidaemic Activities of Solvent Extracts of Ocimum basilicum Leaves in Streptozotocin-induced Diabetic Rats

Authors

  • Ugwu, M. N. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author
  • Umar, I. A. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author
  • Ibrahim, S. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author
  • Ibrahim, M. A. Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria Author

Abstract

Aqueous, methanolic and petroleum ether extracts of Ocimum basilicum leaves at the dose of 200 mg/kg body weight was investigated for hypoglycaemic and hypolipidaemic activities in streptozotocin-induced diabetic rats. Oral administration of 200 mg/kg of the solvent extract for 35 days resulted in a significant reduction (P<0.05) in the fasting blood glucose levels of streptozotocin-induced diabetic rats. The extracts at the dose of 2 g/kg body weight enhanced the glucose clearance of the streptozotocin-induced diabetic rats. The extracts significantly (P<0.05) reduced the total cholesterol, triglycerides and LDL-cholesterol in all treated groups when compared with the diabetic control with significantly (P<0.05) higher values of HDL-cholesterol. The extracts exhibited hypoglycaemic and hypolipidaemic activities in the diabetic rats and hence may be the basis for its folkloric use in the management of diabetic patients in Nigeria.

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References

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Published

2011-12-30

How to Cite

Hypoglycaemic and Hypolipidaemic Activities of Solvent Extracts of Ocimum basilicum Leaves in Streptozotocin-induced Diabetic Rats. (2011). Nigerian Journal of Biochemistry and Molecular Biology, 26(2), 126-134. https://www.nsbmb.org.ng/journals/index.php/njbmb/article/view/276