Antiplasmodial and Haematopoietic Activities of Ethanolic Extract of some Chinese Green Tea in Plasmodium berghei-infected Mice
Abstract
In the present study, we evaluated the antiplasmodial and haematopoietic activities of 200 mg/kg and 400 mg/kg body weight of crude ethanolic extracts of three commercial Chinese green tea (BIA 849, TD 570 and GB/T19598) using the 4-day suppressive and Rane’s curative anti-malarial assays in mice infected with Plasmodium berghei (NK65 strain). Effect of the extracts on weight was also determined. Ethanolic extract of the green tea produced a significant (p<0.05) dose dependent decrease in the parasitemia level in the test groups comparable to the chloroquine treatment group. 400 mg/kg bw of TD570 and GB/T19598 green tea produced significant (p<0.05) increase in parasitemia suppression while BIA 849 suppressive activity did not change significantly with dose. The curative and chemo suppression activities of TD570 and GB/T19598 at 4 days post treatment were significantly (p<0.05) higher than 5 mg/kg bw of chloroquine having 100 % curative activities at 2 and 3 days post treatment, respectively and 100 % chemo suppression. Chemosuppression activity of BIA 849 did not change significantly (p>0.05) at 400 mg/kg bw. compared with same dose of TD570 and GB/T19598 green tea. Significant (p<0.05) increase in haematopoiesis during suppressive and curative treatment of malaria were respectively shown by 200 mg/kg and 400 mg/kg bw. of these tea. BIA 849 produced significant (p<0.05) increased haematopoiesis compared to the other two. There was significant (p<0.05) increase in weight in mice treated with 200 mg/kg TD 570 compared to the controls while the weight of mice treated with 400 mg/kg GB/T19598
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