Preliminary studies of antidote to snake venom from plant based materials
Abstract
The ability of the plant extract "Danya" (Sc/erocarya birrea) to neutralize the necrotic and haemorrhagic effect of
Naja naja and Naja nigricol/is venom was investigated. The plant extract of various doses were pre-incubated with the venoms
for 30 minutes at room temperature prior to intramuscular administration to rats. Cold extract of this plant completely
neutralized the necrotic and haemorrhagic effect of the two venoms. Cold extract of this plant also exhibited a heat stable
anticoagulant property. This anticoagulant property was found to reside in the chloroform fraction of the extract which could be
responsible for the neutralization of necrotic and haemorrhagic effect of the venoms. The identity of this neutralization factor
and/or the anticoagulant substance(s) is currently under investigation.
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References
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