Biochemical and Haematological Responses to Chronic Consumption of some Herbalized Nigerian Alcoholic Drinks
Keywords:
biochemical changes, alcoholic beverages, haematological parameters, wistar ratAbstract
The unconfirmed perceptions of herbal-based alcoholic beverages having therapeutic, anti-malarial, and aphrodisiac properties have led to a surge in use of these products in many poor nations. Herein, we investigated biochemical and haematological effects of some commonly consumed herbalized alcoholic beverages in Cross River State, Nigeria using rat. Male wistar rats were treated with Action bitters, Alomo bitters, Origin bitters, 1960 bitters, Local gin, and Local gin plus vitamin B-complex, daily at a dose of 2.68 mL/kg body weight. A control group was given distilled water. After 90 days exposure, rats were anaesthetized in chloroform vapour and blood collected via cardiac puncture. Serum biochemical parameters; total protein, albumin, creatinine, and haematological parameters; haemoglobin, red blood cell, packed cell volume, platelet, white blood cell, basophils, neutrophils, eosinophils, lymphocyte and monoctes were measured. There were significant decreases (P < 0.05) in total protein and albumin of groups that received local gin, and local gin + vitamin B-complex. Also, the creatinine in all the alcohol-treated groups were significantly decreased (P < 0.05), compared with control. These suggest hepato and nephro-toxicities were significantly decreased (P < 0.05) in alcohol-treated groups compared with control group, suggesting haemato-toxicity. The results further showed that Local Gin induced more pronounced deleterious biological effects compared to other tested alcoholic beverages. Overall, the decrease in biochemical and haematological parameters in treatment groups compared with control suggests a probable mode of action and provide a mechanistic insight by which alcoholic beverages induce biochemical and haematological toxicity.
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Copyright (c) 2022 Michael O. Odey, Mboso E. Ofonime, Ironya Ogar, Iwara A. Iwara, Eze A. Adindu, Chukwuemeka O. Godfrey, Mbang E. Ibor, Markpeace E. Osim, Edward O. Emuru
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