Hepatoprotective and Nephroprotective Effects of Chrysophyllum albidum Aqueous Fresh Leaf Extract in Albino Rats
Keywords:
Chrysophyllum albidum, liver, kidney, liver function parameters, kidney function parameters, albino rats.Abstract
Chrysophyllum albidum fruit is widely consumed and used in many parts of Africa for the management and treatment of various diseases, including liver and kidney impairments. Hence, this study determined the effects of C. albidum aqueous fresh leaf-extract on the hepatic and renal markers of albino rats. Sixteen adult male albino-rats were grouped into four with four rats each. Normal control was group A, while those administered with dosages of 200 mg/kg, 400 mg/kg and 600 mg/kg body weight of C. albidum aqueous fresh leaf extract twice daily via oral intubation for seven consecutive days were respectively groups B, C and D. Blood collected through cardiac puncture from the rats were used for liver and kidney function assays. Liver function markers tested were alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein and total bilirubin. The kidney function markers tested were urea, creatinine, sodium, bicarbonate and potassium. The activities of ALP, AST and ALT significantly (p < 0.05) decreased, as well as the concentrations of total protein, total bilirubin, urea, creatinine, bicarbonate (HCO3-), sodium (Na+) and potassium (K+) in the extract-treated groups (B, C, D) in accordance to the dosage, unlike the normal control (A). Our findings suggest that C. albidum leaf has both hepatoprotective and nephroprotective effects, hence, may be useful for managing and treating of liver and/or kidney diseases.
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