Hypolipidemic Impact of ‘Aju Mbaise’ Herbal Mixture in Type II Diabetic Female Rats
DOI:
https://doi.org/10.4314/njbmb.v40i1.11Keywords:
Aju Mbaise, Cholesterol, Combined Multiple Plant Extract, Diabetes, HypolipidemiaAbstract
This study was conducted to evaluate the hypolipidemic potential of the combined multiple plant extract (CMPE) of Sphenocentrum jollynum, Cnestis ferruginea, Xylopia aethiopica, Uvaria chamae, Palisota hirsuta, Scleria sp., Napoleona sp., Dialium guineense, Combretum racemosun, and Heterotis rotundifolia commonly referred to as ‘Aju Mbaise’ in South Eastern Nigeria. The study involved fifty-four (54) rats grouped into 6 with 9 rats per group. The groups include the normal control (NC), diabetic control (DC), metformin treated group, and three diabetic treated groups that received different concentrations (500 mgkg-1, 250 mgkg-1, and 100 mgkg-1) of the CMPE correspondingly. Diabetes was ascertained after high fat diet (HFD) and streptozotocin (STZ) administration. Total cholesterol (TC), triglyceride, high-density lipoprotein (HDL) and low-density lipoproteins (LDL) were assayed accordingly at interval of four weeks and results obtained revealed significant reduction in concentrations of total cholesterol (1.49±0.33 mmol/l), triglyceride (0.95±0.18 mmol/l), LDL (1.34±0.57 mmol/l), as well as increased HDL (1.38±0.22 mmol/l) at week 12, in the diabetic animals treated with 250mg/kg body weight of the CMPE. This study revealed a positive hypolipidemic effect of the multiple plants extracts. Thus, it could be employed as a potential therapy for managing the risks associated with cardiovascular diseases.
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Copyright (c) 2025 Chinonso U. Nnadiukwu, Tochukwu A. Nnadiukwu (Author)
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