Antioxidant Capacity of Methanol Extract of Gymnema sylvestre Leaves and its Effect on Some Physical and Biochemical Parameters of Potassium Bromate Treated Rats
Keywords:
Toxicity, potassium bromate, remedyAbstract
ABSTRACT
This study investigated the antioxidant capacity of methanol extract of Gymnema sylvestre (gurmar) leaf and its effect on some physical and biochemical parameters in potassium bromate-treated rats. Group 1: control rats, group 2: rats administered methanol extract of Gymnema sylvestre leaf (200 mg / kg bwt), group 3: rats administered extract of Gymnema sylvestre leaf (500 mg / kg bwt), group 4: (KBrO3) - treated rats (20 mg / kg, bwt), group 5: rats treated with KBrO3 (20 mg / kg bwt) and extract of Gymnema sylvestre leaf (200 mg / kg bwt) and group 6: rats treated with KBrO3 (20 mg / kg bwt) and extract of Gymnema sylvestre leaf (500 mg /kg bwt). Antioxidant activity of G. sylvestre was carried out using Ferric Reducing Antioxidant Power (FRAP) and 2, 2- Diphenyl-1-picrylhydrazyl (DPPH) assays. Serum electrolyte concentrations of K+, Na+ and Cl- were determined using an automatic electrolyte analyzer. Methanol extracts of G. sylvestre leaf exhibited antioxidant activity against free radicals. In the in vivo study, there was a significant decrease (p˂0.05) in the weight of liver and increase in weight of kidney of rats in KBrO3 treated group compared with the control group. There was also significant increase in the serum electrolyte concentration of rats in KBrO3 treated group. However, this was reversed following the administration of methanol extracts of G. sylvestre to the KBrO3-treated groups. The result of this study suggests that the methanol extract of the leaves of gurmar has the potential to ameliorate KBrO3-induced toxicity in wistar rats.
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Copyright (c) 2026 Ele-Ojo Ataguba, Eniola J. Olajide, Musa Amanabo (Author)
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