Association of Maternal Lipid Profile, Nutritional Status, and Gestational Diabetes Mellitus in Pregnant Women Attending General Hospital, Dutse, Jigawa State, Nigeria
DOI:
https://doi.org/10.4314/njbmb.v40i1.12Keywords:
Diabetes, Gestational Diabetes, Hyperglycemia, Pregnancy, Metabolic DiseasesAbstract
Gestational Diabetes is one of the most prevalent metabolic disorder during pregnancy that affects about 25% of pregnancies in some countries and associated with changes in lipid profile of pregnant women. This study analyzes the changes in lipid profile in patients with GDM. An oral glucose tolerance test (OGTT) was used to determine the existence of GDM among the study participants. Serum iron, zinc, calcium, albumin and lipid profile markers including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were determined. The study revealed elevated levels of TC (80.0% high TC as against 2.2% with normal TC), TG (41.4% high TG as against 2.3% with normal TG), HDL (55.6% high HDL as against 7.1% with normal HDL), and LDL (91.7% high LDL as against 4.2% with normal LDL) in patients with GDM. The participants demonstrated variations in key health indicators, with mid-upper arm circumference (MUAC) (69.6%) and albumin (71.7%) within the normal range. The calcium (2.22 mmol/l) level slightly exceeded the normal range. However, iron (117.76mg/dl) and zinc (77.00 mg/dl) levels remained within normal levels. The study underscored relationships between lipid profile, zinc, albumin and GDM status (p<0.05). Conclusively, pregnancies affected by GDM are characterized by dyslipidaemia, thus advanced lipid testing may indicate disturbed lipid homeostasis in GDM.
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Adegbija, O. E., and Adegbija, O. J. (2020). Evaluation of Lipid Profile and Cardiometabolic Risk among Pregnant Women Attending Antenatal Clinics in Osogbo, Nigeria. Nigerian Medical Journal, 61(3): 125.
Aghaie, Z., Hajian, S. and Abdi, F. (2018). The relationship between lipid profiles in pregnancy and preterm delivery: A systematic review. Biomedical Research and Therapy, 5(8):2590–609. [Google Scholar]
Alavi, N. M., Alijahan, R., and Ahmadi, M. (2018). Prevalence of dyslipidemia in Iranian pregnant women: a systematic review and meta-analysis. BMC Pregnancy and Childbirth, 18(1):1-13.
Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W. F. P. C., and Fu, P. C. (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry, 20(4): 470-475.
Antwi-Baffour, S., Kyeremeh, R., Boateng, S.O., Annison, L. and Seidu, M.A. (2018). Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana. Lipids in health and Disease, 17(1):1–9.
Azeez, T. A., Briggs, T. A., and Adeyanju, A. S. (2021). A systematic review and meta ‑ analysis of the prevalence and determinants of gestational diabetes mellitus in Nigeria. The New Indian Journal of OBGYN,9(2): 194-203. doi.org/10.21276/0bgyn.2023.9.2.2
Benhalima, K., Van Crombrugge, P., Moyson, C., Verhaeghe, J., Vandeginste, S., Verlaenen, H., Vercammen, C., Maes, T., Dufraimont, E. and De Block, C. (2019) Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance. Diabetologia 62: 2118–2128.
Bohn, M.K. Adeli, K. (2022). Physiological and metabolic adaptations in pregnancy: Importance of trimester-specific reference intervals to investigate maternal health and complications. Critical Reviews in Clinical Laboratory Sciences, 59: 76–92.
Celik, H., Avci, E. M., Atalay, A., and Yildirim, G. (2015). Evaluation of dyslipidemia and lipid peroxidation status in pregnant women. International Medical Journal, 4(1):1826-1835.
Clark, W.L, Baginski E.L, Marie S.S. and Zak B. (1974). Spectrometric study of direct determination of serum calcium. Microchemical journal, 20:22-32
Cogill, Bruce (2003). Anthropometric Indicators Measurement Guide. Washington, DC: Food and Nutrition Technical Assistance (FANTA) Project, FHI 360.
Doumas B. T., Arends R. L. and Pinto P. C. (1972). Standard Methods of Clinical Chemistry. Academic Press of Chicago,7:175-189
Elsayed, E. T., Aly, H. A., Khafagy, A. A. and Elsayed, G. M. (2021). Dyslipidemia in pregnancy-induced hypertension and gestational diabetes mellitus: A pilot study. Egyptian Journal of Basic and Applied Sciences, 8(1): 17.
Farren, M., Daly, N., O'Higgins, A. C. and McKeating, A. (2019). The association between maternal lipids and perinatal outcomes in women with gestational diabetes mellitus (GDM). Journal of Perinatology, 39(11):1544-1550.
Friedewald, W. T., Levy, R. I. and Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18: 499–502.
Habibi, N., Mousa, A., Tay, C.T., Khomami, M.B., Patten, R.K., Andraweera, P.H., Wassie, M., Vandersluys, J., Aflatounian, A. andBianco-Miotto, T., (2022). Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta-analysis. Diabetes Metabolism Research and Review, 38: e3532.
Herrera, E. andDesoye, G. (2016). Maternal and fetal lipid metabolism under normal and gestational diabetic conditions. Hormone Molecular Biology and Clinical investigation, 26(2):109–27.
Hod, M., Kapur, A., Sacks, D.A., Hadar, E., Agarwal, M. and Di Renzo, G.C. (2015). The international federation of gynecology and obstetrics (FIGO) initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care. International Journal of Gynecology and Obstetrics, 131: S173–211.
Homsher, R., Zak, B. (1985). Spectrophotometric investigation of sensitive complexing agents for the determination of zinc in serum. Clinical Chemistry, 31(8): 1310–1313
Jacobs, N.J., and Vandemark, P.J. (1960). The purification and properties of the αglycerophosphate-oxidizing enzyme of Streptococcus faecalis 10C1. Archives of Biochemistry and Biophysics, 88(2): 250-255.
Kampmann, U., Knorr, S., Fuglsang, J. and Ovesen, P. (2019) Determinants of maternal insulin resistance during pregnancy: An updated overview. Journal of Diabetes Research, 2019, 5320156.
Kumar, N., Singh, A. K. and Rai, A. K. (2016). Dietary diversity and its relationship with nutritional status among pregnant women in Patiala, Punjab. Indian Journal of Community Health, 28(2):184-189.
Li, M., Hou, X., Zhang, R., Zheng, X. and Dang, W. (2022). Role of apolipoprotein E in suppressing oxidative stress in gestational diabetes mellitus patients and mouse model. International Journal of Gynecology and Obstetrics, 159: 204–212.
Li, N., Fu, J., Koonen, D.P., Kuivenhoven, J.A., Snieder, H. and Hofker, M.H. (2014). Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance? Atherosclerosis, 233: 130–138.
Makino, T., Kiyonaga, M. and Kina, K. (1988). A sensitive, direct colorimetric assay of serum iron using the chromogen, nitro-PAPS. Clinica Chimica Acta, 171(1): 19-27.
Mirzamoradi, M., Asemi, Z. and Esmaillzadeh, A. (2017). Soy intake, cardiometabolic risk factors and gestational diabetes. Journal of Clinical Endocrinology and Metabolism, 101(2): 465-472.
Muche, A. A., Olayemi, O. O. and Gete, Y. K. (2019). Prevalence and determinants of gestational diabetes mellitus in Africa based on the updated international diagnostic criteria: A systematic review and meta-analysis. Archives of public health, 77(36):1–20.
Oguizu, A. D. (2015). Assessment of Iron Selenium and Zinc Status of Pregnant Women in ObioAkpor Local Government Area, Rivers State. Pakistan Journal of Nutrition. 14(1): 1-5.
Reddi Rani, P. and Begum, J. (2016). Screening and diagnosis of gestational diabetes mellitus, where do we stand. Journal of Clinical and Diagnostic Research, 10(4): QE01–QE04. https://doi.org/10.7860/JCDR/2016/17588.7689
Saravanan, P., Magee, L. A., Banerjee, A., Coleman, M. A., Von Dadelszen, P., Denison, F., Farmer, A., Finer, S., Fox-Rushby, J., Holt, R., Lindsay, R. S., MacKillop, L., Maresh, M., McAuliffe, F. M., McCance, D., McCarthy, F. P., Meek, C. L., Murphy, H. R., Myers, J. and Williamson, C. (2020). Gestational diabetes: opportunities for improving maternal and child health. The Lancet Diabetes and Endocrinology, 8(9):793–800
Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy. Clinical Chemistry and Laboratory Medicine, 50: 2019–2025.
Stewart, Z. A. (2019). Gestational diabetes. Obstetrics, Gynaecology and Reproductive Medicine, 30(3): 79–83. https://doi.org/10.1016/j.ogrm.2019.12.005.
Wang, J., Li, Z. and Lin, L. (2019). Maternal lipid profiles in women with and without gestational diabetes mellitus. International Journal of Medicine. 98(16):15320.
Yang, X., Leng, J., Liu, H., Wang, L., Li, W., Li, W., Yang, X., Liu, M. and Hu, G. (2021). Maternal gestational diabetes and childhood hyperlipidemia. Diabetic Medicine, 38: e14606.
Yang, Y. and Wu, N. (2022). Gestational diabetes mellitus and preeclampsia: Correlation and influencing factors. Cardiovascular Medicine, 9: 831297.
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The laboratory data used to support the findings of this study are available from the corresponding author upon request.
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Copyright (c) 2025 Hadiza Abubakar, Danladi A. Ameh, Ismaila A. Umar (Author)
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