Curative Influence of Natural Honey Bee on Liver Function Parameters in Aluminium Nitrate-induced Wistar Rats
The search for antidotes for Al toxicity is on-going. Thus, this study investigated the curative influence of natural honey bee on liver function parameters in aluminium nitrate-induced Wistar rats. Thirty (30) Wistar rats (150±6g) were divided into six groups: Group one served as control and received only feed and water. Groups 2-6 served as the test groups and received single dose of Al(NO3)3 (6.5 mg/kg body weight). Groups 3-6 received varying doses of NBH (10 %, 25 %, 50 % diluted with distilled water and 100 % natural BH orally at a dose of 2.5 g/kg respectively) 24 h after Al(NO3)3 intoxication for 14 consecutive days. The activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the plasma and liver and the levels of total protein, albumin and globulin were evaluated. Exposure to aluminium significantly (p< 0.05) increased the activities of ALT, AST and ALP relative to rats in the control group. However, the treatment of Al-exposed rats with varying doses of NBH significantly reduced the activities of the enzymes, compared to rats maintained on Al alone, with the exception of Al-exposed rats given 100 % NBH. Albumin concentrations were significantly higher in control rats than in rats exposed to Al. However, the administration of 50% NBH to Al-exposed rats significantly (p< 0.05) increased albumin concentration relative to rats exposed to Al alone. This study showed that NBH has significant positive effects on aluminum toxicity in rats with the 50 % NBH treatment having the greatest effect.
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