The Leaf Extract of Carica papaya alleviates Benign Prostate Hyperplasia in male Albino rats by Antioxidative Mechanisms
Keywords:Antioxidants, benign prostate hyperplasia, Inflammation, Carica papaya.
The pathology of many disorders in humans such as inflammation has been linked with free radical activities. This study was done to evaluate the potential ameliorative action of Carica papaya leaf extract on benign prostatic hyperplasia which is highly prevalent today. The animals were grouped randomly into six with fiverats in each group. Group 1 served as normal control, while groups (2–6) were induced with prostate inflammation using 0.08 mg/kg of testosterone and 0.04mg/kg of oestradiol, parenterally for 28 days. Group 2 and 3 served as positive and negative control. The test groups (4-6) were treated with 200, 400 and 800 mg/kg body weight of Carica papaya extract for another 28 days. At the end of the treatment period, blood samples were collected for required biochemical analysis; PSA, testosterone, Dihydrotestosterone (DHT), malondialdehyde, (MDA), glutathione reductase (GR), catalase (CAT) and superoxide dismutase (SOD). The results showed significant (p<0.05) increase in the serum PSA, testosterone, DHT and MDA levels of the animals exposed to the inducing agents, whereas there was a significant (p>0.05) decrease in the activities of GR, CAT and SOD as compared with the normal control. However, treatment with ethanol leaf extract of C. papaya caused significant (p >0.05) decrease in PSA, testosterone, DHT and MDA levels, and there was a significant (p>0.05) increase in the activities of the antioxidant enzymes in a dose dependent manner as comparable to the normal control. These findings are indication that the extract has potential remedial effects on benign prostatic hyperplasia through antioxidant mechanism.
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