Intravaginal Administration of Talc Alters Red Cell Fragility and Lipid Peroxidation in Rats
Abstract
The study was carried out to investigate the effects of fourteen days administration of intravaginal talc solution on erythrocyte indices, osmotic fragility and lipid peroxidation in rats. Intravaginal talc solution was administered for 14 days, following which erythrocyte indices such as red blood cell (RBC) count, haemoglobin concentration (Hb), haematocrit or Packed Cell Volume (PCV), reticulocyte count and erythrocyte osmofragility were determined in addition to plasma malondialdehyde (MDA). The RBC count, Hb, PCV and reticulocyte count were reduced significantly (p<0.05) following 14 days administration of intravaginal talc solution, while erythrocyte osmofragility was significantly elevated (p<0.05). There was also significant increase (p<0.05) in the plasma MDA of talc-treated rats. The study therefore showed that administration of intravaginal talc solution for 14 days may increase red cell osmofragility and lipid peroxidation as well as exhibit anti-erythropoietic properties. In conclusion, it is advisable that caution should be exercised in the administration of talc powder around the perineum of females because of its potential to traverse the female reproductive system and cause systemic damage.
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References
Abraham, J. L. and Brambilla, C. (1980). Particle size for differentiation between inhalation and injection pulmonary talcosis. Environ. Res., 21: 94.
Crouch, E. D. and Churg, A. (1983). Progressive massive fibrosis of the lung secondary to intravenous injection of talc. A pathologic and mineralogic analysis. Am. J. Clin. Pathol., 80: 520.
Farbert, H. W., Fairman, R. P. and Glanser, F. L. (1982). Talc granulomatosis: laboratory findings similar to sacroidosis. Am. Rev. Respir. Dis., 125: 258.
Gawel, S., Wardas, M., Niedworok, E. and Wardas, P. (2004). Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad. Lek., 57(9-10): 453-455.
Heller, D. S., Gordon, R. E., Westhoff, C. and Gerber, S. (1996). Asbestos exposure and ovarian fiber burden. Am. J. Ind. Med. 29:435-439.
International Agency for Research on Cancer (2010). IARC monographs on the evaluation of carcinogenic risks to human, Carbon black, titanium dioxide, and non-asbestiform talc. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 93: 412.
Keskin , N., Teksen, Y. A., Ongun, E. G., Ozay, Y. and Saygili, H. (2009). Does long-term talc exposure have a carcinogenic effect on the female genital system of rats? An experiemtal pilot study. Arch. Gynecol. Obstet., 280(6): 925-931.
Kumar, R., Seth, R. K., Lekhon, M. S. and Bhargava, J. S. (1995). Serum lipid peroxide and other enzyme levels of patients suffering from thermal injury. Burn 21:96-97.
Langseth, H., Johansen, B. V., Nesland, J. M. and Kjaerheim, K. I. (2007). Asbestos fibers in ovarian tissue from Norwegian pulp and paper workers. Int. J. Gynecol. Cancer 17: 44-49.
Langseth, H., Hankinson, S. E., Siemiatycki, J. and Weiderpass, E. (2008). Perineal use of talc and risk of ovarian cancer. J. Epidemiol. Comm. Health, 62: 358-360.
Olaleye, S. B., Iranloye, B. O., Salami, H. A. and Elegbe, R. A. (1999). Erythrocyte osmotic fragility and other blood parameters in rats fed with diets containing raw and processed soya-beans (Glycine max). Boisci. Res. Commun., 11: 107-112.
Olive, D. L. and Schwartz, L. B. (1993). Endometriosis. N. Engl. J. Med., 328: 1759-1769.
Parpart, A. K., Lorenz, P. B., Parpart, E. R., Gregg, J. R and Chane, A. M. (1947). The osmotic resistance of human red blood cells. J. Clin. Invest., 26: 636.
Radić, I., Vučak, I., Milošević, J., Marušić, A., Vukičević, S and Marušić, M. (1988). Immuno-suppression induced by talc granulomatosis in the rat. Clin. Exp. Immunol., 73: 316-321.
Riley, R. S., Ben-Ezra, J. M. and Tidwell, A. (2001). Reticulocyte enumeration: Past and Present. Lab. Med., 30(10): 597-608.
Rosenblatt, K. A. and Thomas, D. B. (1996). Reduced risk of ovarian cancer in women with a tubal ligation or hysterectomy. The World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives. Cancer Epidemiol. Biomarkers Prev., 5: 933-935.
Sheikh, K. M. A., Dugal, K., Relfson, M., Gignac, S. and Rowden, G. (1984). An experimental histopathologic study of surgical glove powders. Arch Surg 119(2):215-219.
Tortolero-Luna, G. and Mitchell, M. F. (1995). The epidemiology of ovarian cancer. J. Cell Biochem. (Suppl) 23: 200-207.
Venter, P. F. (1981). Ovarian epithelial cancer and chemical carcinogenesis. Gynecol. Oncol. 12: 281-285.
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