Effects of Dietary Substitution with Vernonia calvoana Leaf on some Serum Lipid and Haematological Parameters in Male Wistar Rats

Authors

  • Egbung, G. E. Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar, Nigeria Author
  • Ubaba, M. U. Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar, Nigeria Author
  • Atangwho, I. J. Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar, Nigeria Author
  • Egbung, J. E. Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar, Nigeria Author

Abstract

Consumption of green leafy vegetables especially the lesser known types for culinary and medicinal values has been on the increase in the tropics. The present study was designed to evaluate the haemotopoetic and hypolipidaemic effects of dietary substitution with Vernonia calvoana (VC) leaf in male Wistar rats. Twenty-four male Wistar rats weighing 80-140 g were randomly assigned into 4 groups of 6 rats each. Group 1( normal control) received normal rat chow, groups 2, 3 and 4 were maintained on standard rat chow substituted with 5%, 15% and 30% of V. calvoana leaf respectively for 30 days. At the end of the experimental period, the animals were sacrificed and blood samples collected for some biochemical and haematological studies. There was non-significant (p > 0.05) change in serum triacylglycerol, total cholesterol, very low density lipoprotein-cholesterol (VLDLC) and low density lipoprotein-cholesterol (LDLC) concentrations in groups 2, 3 and 4 relative to the control group while serum high density lipoprotein cholesterol increased significantly(p < 0.05) in the group fed 30% V.calvoana supplemented diet relative to the control. The result showed no significant effect (p > 0.05) on the levels of packed cell volume, haemoglobin concentration, lymphocytes and total white blood cell. This finding suggests that the leaf of V. calvoana are non-haematotoxic and may possess positive modulatory effect on serum lipid profile by increasing HDL-C especially at 15% and 30% level of supplementation, hence might be beneficial to the diabetics and obese.

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References

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Published

2018-08-30

How to Cite

Effects of Dietary Substitution with Vernonia calvoana Leaf on some Serum Lipid and Haematological Parameters in Male Wistar Rats. (2018). Nigerian Journal of Biochemistry and Molecular Biology, 33(1&amp;2), 32-43. https://www.nsbmb.org.ng/journals/index.php/njbmb/article/view/289