Some Biochemical Changes in Rats Maintained on High Fat Diets Supplemented with Pennisetum purpureum (Schumach)
Abstract
The effects of graded dietary incorporation of Pennisetum purpureum on plasma lipid profile, oral glucose tolerance test, relative organ and body weight changes in high-fat diet (HFD) fed rats were investigated. Lipid profile estimation was done using standard kits while blood glucose concentration was determined using a glucometer kit. The results show that there were significant (p<0.05) decreases in total cholesterol (TC), triacylglycerol (TAG), LDL-cholesterol (LDL-C) concentrations in animals fed HFD-incorporated with both 10 and 20 % Pennisetum purpureum relative to those fed HFD only. While a significant (p<0.05) increase in HDL cholesterol concentrations was observed in the test rats relative to the animals fed HFDs only. Oral glucose tolerance tests significantly improved in the group fed 10% Pennisetum purpureum. Relative weights of the spleen, kidney, liver, heart and intestine showed no significant (p>0.05) changes relative to the control group fed HFD. These findings are indicative that dietary incorporation of Pennisetum purpureum could modulate blood glucose responses and blood lipid profile in high fat diet fed rats. This may be beneficial to individuals who are predisposed to high fat diet related obesity and its associated metabolic disorders. It may therefore warrant further investigation, perhaps in humans.
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