Evaluation of the Effect of Kigelia africana Seed Oil on the Antioxidant Status of Cisplatin Treated Wistar Rats
Keywords:
Antioxidant, oil, kigelia africana, Seed, malondialdehydeAbstract
Cisplatin is a well-known chemotherapeutic agent that has been successfully used to treat cancer of the lung, neck, bladder, ovary, and testicle. This medication though an important chemotherapeutic agent, has the potential to induce oxidative stress. The aim of this study was to evaluate the effect of Kigelia africana seed oil (KASO) on the antioxidant status and lipid profile of Wistar rats Administered to cisplatin. A total of 48 adult male albino rats were divided into six groups of 8 rats each. Group I (normal control) was fed only rat chow. Groups II–VI were administered 7 mg/kg of cisplatin. Groups III-V were administered 0.5, 1, 1.5 ml/kg of KASO, and group VI was administered 0.5 ml/kg of omega-3 oil. Oil administration lasted for 21 days, after which blood samples were drawn from the animals by cardiac puncture. Biochemical parameters were determined using standard procedures. The results obtained from this study showed that cisplatin markedly lowered antioxidant (superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSR)) and raised malondialdehyde (MDA). However, a contrary observation was made following the administration of KASO. In conclusion, it can be deduced that Kigelia africana seed oil can mitigate cisplatin induced oxidative stress by enhancing antioxidant enzyme activities and reducing lipid peroxidation. Thus, may be ideal for use as an adjuvant to ameliorate chemotherapy-induced oxidative stress.
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Copyright (c) 2026 Chukwudi Uguru, Christian E. Offor, Ekpono E. Ugbala, Aja P. Mmaduabuchi, Ikechuku O. Igwenyi, Fredrick O. Orinya, Anestesia E. Onya-Mmaghiri, Nwuruku O. Alfred, Onwe F. Ogba, Ewa Ogbonnaya, Ejiofor D. Chinedu, Agu K. Akachukwu (Author)
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