Gastroprotective Effect of Methanol Extract of Spondias mombin Stem Bark in Acidified Ethanol-Induced Ulcer in Rats
Keywords:
Spondias mombin, gastric ulcer index, mucosal necrosis, percentage ulcer protection.Abstract
Ulcer is one of the major diseases faced by the world population. This disease comes with gastrointestinal discomfort and sometimes leads to complications if untreated. Many synthetic drugs are helpful, but they are associated with many side effects. Therefore, there is a need to search for natural herbal medications that are potent and safe for ulcer treatment. This study evaluated the ulcer protective effect of methanol extract of Spondias mombin stem bark using acidified ethanol-induced ulcer model. Twenty-four adult rats of 82 – 130g body weight were divided into six groups of four rats per group (n=4). Animals were treated with varying doses (100, 200 and 500 mg) per kilogram body weight of methanol extract of S. mombin stem bark for two weeks. Groups treated with 100, 200 and 500 mg/kg b.w of methanol extract of S. mombin stem bark extract showed dose-dependent percentage ulcer protection of 16, 42 and 66% respectively compared to the untreated disease control group with zero percentage ulcer protection. Group treated with 500 mg/kg b.w of extract has total gastric acidity of 7.80 ± 1.72 mmol/L, which showed a significant (P < 0.05) decrease in total gastric acidity compared to the untreated group with total acidity of 17.75 ± 4.79 mmol/L. Methanol extract of S. mombin stem bark possesses ulcer protective effect against mucosal damage by acidified ethanol-induced ulcer in rats. This supports the claim of traditional herbal use of S. mombin stem bark for ulcer treatment.
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Copyright (c) 2026 Ifeoma U Eze, Emenike B Amadi, Chizoba J Anosike, Christian C Amah, Chioma A Anosike (Author)
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