Effect of Resveratrol on Haematological Changes in Diabetic-Malaria Infected Wistar Rats


  • Fatimah A. Dawud Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria Author
  • Saifullahi Abdullahi Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria Author
  • Jimoh Abdulazeez Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria Author
  • Farrau Usman Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria Author
  • Joseph O. Ayo Department of Veterinary Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria Author


Diabetes, Rats, Resveratrol, Haematological Indices, Malaria, Parasitaemia


The effect of resveratrol on haematological changes in diabetic-malaria infected rats was investigated. Five of six groups of male Wistar rats were induced with type 2 diabetes, followed by inoculation with malaria parasites. Four groups of the diabetic-malaria infected rats were orally given: low dose resveratrol (50 mg/kg), high dose resveratrol (100 mg/kg), Metformin (100 mg/kg) and Artesunate (5 mg/kg) respectively for six days after malaria inoculation. Administration of resveratrol, metformin and artesunate to diabetic-malaria infected rats significantly (p < 0.05) decreased the blood glucose level (BGL) on days 3 and 6 post-inoculation. The high dose resveratrol (RSV 100) group showed a significant (p<0.05) increase in red blood cell counts, although a significant (p < 0.05) decrease of Packed Cell Volume was recorded in the low dose resveratrol group.  There was no significant (p>0.05) difference for the values of total WBC counts across the four groups of the diabetic-malaria infected rats, but the differential WBC counts (dWBCC) were significantly (p<0.05) affected. High dose resveratrol administration significantly (p < 0.05) reversed the dWBCC. The diabetic-malarial infected group showed significant (p<0.05) decrease in average RBC; the average parasites and average infected RBC counts were significantly (p<0.05) higher than that in the resveratrol groups. While, Metformin and Artesunate groups showed a further decline in parasitaemia. These findings indicate that Resveratrol decreased BGL and improved hematological parameters and suppressed parasitaemia in diabetic-malarial infected rats.


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How to Cite

Effect of Resveratrol on Haematological Changes in Diabetic-Malaria Infected Wistar Rats. (2023). Nigerian Journal of Biochemistry and Molecular Biology, 38(3), 147-153. https://www.nsbmb.org.ng/journals/index.php/njbmb/article/view/377

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