Antidiabetic Activity of Chloroform Extract of Carica papaya Cuticular Lipids (CECC) in Alloxan-Induced Diabetic Rats
Keywords:
Antidiabetic, alloxan , serum lipid profile, carica papaya, Blood glucoseAbstract
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia. It is associated with various complications if not properly managed. This study was aimed to investigate the antidiabetic effects of chloroform extract of Carica papaya cuticular lipids (CECC) in alloxan-induced diabetic rats. In this study, CECC at 250, 500, 1000 and 2000 mg/kg body weight were administered to alloxan-induced diabetic rats for 21 days. Fasting blood glucose (FBG) level, lipid profile, liver and kidney function tests were conducted. All diabetic rats had initial FBG level ≥200 mg/dL 72 hours after the induction. The extract was found to be safe up to the dose of 5000 mg/kg BW after acute toxicity studies. Oral administration of CECC significantly (p< 0.05) reduced FBG level, liver enzymes activities, serum potassium, bicarbonate and serum lipids levels (TC, TG, and LDL) in diabetic rats. Significant (p<0.05) increase in serum HDL was also noted in diabetic rats. This study concluded that the CECC have potential therapeutic effect in diabetes and related complications.
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Copyright (c) 2026 Muhammad M. Usman, Abdullahi Nasir, Muntari Bala, Salahuddeen Ya’u, Ibrahim H. Kankia, Aliyu I. Yar’adua, Umma A. Idris, Ahmad Sani, Aminu Usman, Akilu S. Abdullahi, Nasiruddeen U. Matazu (Author)
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