Nephroprotective Effect of Ipomoea Cairica Leaf Extract against Cadmium-Induced Renal Damage
Keywords:Renal injury; heavy metals; phytochemicals; cadmium; Ipomoea cairica; antioxidant
Cadmium is a toxic heavy metal whose presence has been reported in both children and adults. Accumulation of cadmium in the body can lead to kidney failure. Ipomoea cairica is one of the most underutilized medicinal plants in Nigeria, despite its numerous health benefits. This research investigated the nephroprotective effect of I. cairica leaf 80% methanolic extract against cadmium-induced renal damage. Twenty-eight male Wistar rats were divided into four groups of seven animals per group. Group I- control; group II- single intraperitoneal administration 35 mg/kg of cadmium chloride (CdCl2); III- orally administered 100 mg/kg I. cairica extract (ICE) for five days + 35 mg/kg CdCl2; IV- orally administered 250 mg/kg ICE + CdCl2. The results show that cadmium caused a significant increase in serum concentration of urea, creatinine, and uric acid, compared to the control. Furthermore, cadmium-induced oxidative stress was evident in the kidney tissue, with significant increase in MDA concentration, decrease in glutathione concentration, catalase, superoxide dismutase, and glutathione transferase activity. In conclusion, the results revealed that I. cairica is a good medicinal plant that can be used in maintaining renal function against oxidative stress-induced toxicants as treatment with ICE protected the kidney against cadmium intoxication.
Aebi, H. (1974). Catalase. In Methods of enzymatic analysis (pp. 673-684). Academic press.
Alterio, V., Langella, E., De Simone, G., and Monti, S. M. (2015). Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosiraweissflogii. Marine drugs, 13(4), 1688-1697.
Ansaria, M. A., Raish, M., Ahmad, A., Alkharfy, K. M., Ahmad, S. F., Attiaa, S. M., Alsaad, A. M. S., and Bakheet, S. A. (2017). Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-kB downregulation. Environmental Toxicology and Pharmacology, 51, 100-107
Arao, T. (2019). Mitigation strategies for cadmium and arsenic in rice. In Cadmium Toxicity (pp. 125-138). Springer, Singapore.
Ashraf, V. K. M., Kalaichelvana, V. K., Venkatachalama, V. V., Ragunathan, R. (2020). In vitro anticancer potential of aerial parts of Ipomoea horsfalliae hook in different human cancer cell lines. Industrial Crops and Products, 155, 112746
Ashizawa, A., Faroon, O., Ingerman, L., Jenkins, K., Tucker, P., and Wright, S. (2012). Toxicological Profile for Cadmium. In Agency for Toxic Substances and Disease Registry; Public Health Service U.S. Department of Health and Human Services: Atlanta, GA, USA, 2012; pp. 51–87.
Bekheet, S. H., Awadalla, E. A., Salman, M. M., and Hassan, M. K. (2011). Bradykinin potentiating factor isolated from Buthusoccitanus venom has a protective effect against cadmium induced rat liver and kidney damage. Tissue and Cell, 43(6), 337–343.
Bulmer, F. M. R., Rothwell, H. E., & Frankish, E. R. (1938). Industrial cadmium poisoning: a report of fifteen gases, including two deaths. Canadian Public Health Journal, 29(1), 19-26.
Casado, M., Anawar, H. M., Garcia-Sanchez, A. and Regina, S. I. (2008). Cadmium and zinc in polluted mining soils and uptake by plants (El Losar mine, Spain). International Journal of Environment and Pollution, 33(2-3), 146–159.
Deepa, S. and Shukla, K. (2015). Ipomoea cairica: a medicinal weed with promising health benefits. International Journal of Information Research and Review, 2(5), 687694
Deevika, B, Asha, S., Taju, G. and Nalini, T. (2012). Cadmium acetate induced nephrotoxicity and protective role of curcumin in rats. Asian Journal of Pharmacology and Clinical Research, 5 (3), 186–188.
Dua, T. K., Dewanjee, S., Khanra, R., Bhattacharya, N., Bhaskar, B., Zia-Ul-Haq, M., and De Feo, V. (2015). The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism. Journal of Translational Medicine, 13(1), 1-19.
El-Sharaky, A. S., Newairy, A. A., Kamel, M. A. and Eweda, S. M. (2009). Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food and Chemical Toxicology, 47 (7), 1584–1590
Erboga, M., Kanter, M., Aktas, C., Sener, U., FidanolErboga, Z., Bozdemir Donmez, Y. and Gurel, A. (2016). Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and antioxidant properties. Biological Trace Element Research, 170(1), 165–172.
Gabr, S. A., Alghadir, A. H. and Ghoniem, G. A. (2019). Biological activities of ginger against cadmium-induced renal toxicity. Saudi Journal of Biological Sciences 26(2), 382–389
Genchi, G., Sinicropi, M. S., Lauria, G., Carocci, A. and Catalano, A. (2020). The Effects of Cadmium Toxicity. International Journal of Environmental Research and Public Health, 17(11), 3782
Habig, W. H., Pabst, M. J. and Jakoby, W. B. (1974). Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249(22), 7130–7139.
Hagino, N. and Yoshioka, Y. (1960). A study of the etiology of Itai-Itai disease. Journal of Japanese Orthopedic Association, 35, 812–815.
Horiguchi, H. (2019). Cadmium exposure and its effects on the health status of rice farmers in Akita prefecture. In Cadmium Toxicity (pp. 75-83). Springer, Singapore.
Jiao, Q., Jiang, Y., Liu, Y. and Ji, L. (2019). Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress–induced MAPK and NF-kB pathway in Sprague Dawley rats. Human and Experimental Toxicology, 38(9), 1–10
Joardar, S., Dewanjee, S., Bhowmick, S., Dua, T. K., Das, S., Saha, A., & De Feo, V. (2019). Rosmarinic acid attenuates cadmium-induced nephrotoxicity via inhibition of oxidative stress, apoptosis, inflammation and fibrosis. International Journal of Molecular Sciences, 20(8), 2027.
John, G. N., Onwugbuta, G. C., Chima, D. (2021). Phytochemical and Proximate Analysis of Ipomoea cairicaTuber. Global Journal of Pure and Applied Sciences, 27(1), 11-16
Jollow, D. J., Mitchell, J. R., Potter, W. Z., Davis, D. C., Gillette, J. R. and Brodie, B. B. (1973). Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. Journal of Pharmacology and Experimental Therapy, 187(1), 195–202
Karunakaran, C. and Dhanalakshmi, R. (2009). Selectivity in photocatalysis by particulate semiconductors. Center for European Chemistry, 7: 134–137. [CrossRef]
Kim, K. S., Lim, H.-J., Lim, J. S., Son, J. Y., Lee, J., Lee, B. M., Chang, S. C. and Kim, H. S. (2018). Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. Food and Chemical Toxicology, 114, 34-40
Lin, R., Chen, C. and Lo, W. (2008). Cytotoxic activity of Ipomoea cairica. Natural Product Research, 22 (9), 747-753
Lokhande, B., Patil, P.S. and Uplane, M.D. (2004). Studies on cadmium oxide sprayed thin films deposited through non-aqueous medium. Material Chemistry and Physics, 84, 238–242.
Luo, T., Liu, G., Long, M., Yang, J., Song, R., Wang, Y., Yuan, Y., Bian, J., Liu, X., Gu, J.,Zou, H. and Liu, Z. (2016). Treatment of cadmium-induced renal oxidative damage in rats by administration of alpha-lipoic acid. Environmental Science Pollution and Research International, 24 (2), 1832–1844.
Manna, P., Sinha, M. and Sil, P. C. (2009). Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids, 36(3), 417–428.
Matovic´, V., Buha, A., Ðukic´-C´ osic´, D. and Bulat, Z. (2015). Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys. Food and Chemical Toxicology, 78, 130–140.
Misra, H. P. and Fridovich, I (1972). The univalent reduction of oxygen by reduced flavins and quinones. Journal of Biological Chemistry, 247 188–192.
Mona, T., Heba, M. A., Eman, S., Khadiga, S. I. and Safaa, E. (2018). Impact of occupational cadmium exposure on bone in sewage workers. International Journal of Occupational and Environmental Health, 24: 101–108.
Nazima, B., Manoharan, V. and Miltonprabu, S. (2015). Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements. Biochemistry andCell Biology, 93(3), 210–226.
Ognjanovic´, B. I., Markovic´, S. D., Ethordevic´, N. Z., Trbojevic´, I. S., Stajn, A. S. and Saicic´, Z. S. (2010). Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q (10) and vitamin E. Reproductive Toxicology, 29(2), 191–197.
Ralte, V. (2015). Evaluation of phytochemical contents of Ipomoea cairica(L) Sweet – a qualitative approach. Science Vision, 14 (3), 145-151
Renugadevi, J. and Prabu, S. M. (2010). Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental Toxicology and Pathology, 62(2), 171–181.
Satarug, S. (2019). Cadmium sources and toxicity. Toxics, 7(2), 25.
Satarug, S. (2018). Dietary cadmium intake and its effects on kidneys. Toxics, 6(1), 15.
Shi, Z. Carey, M. Meharg, C. Williams, P. N., Signes-Pastor, A. J., Triwardhani, E. A., Pandiangan, F. I., Campbell, K., Elliott, C., Marwa, E. M., et al. (2020). Rice grain cadmium concentrations in the global supply-chain. Exposed Health, 12 (4), 869-876.
Singh, N. P. (1988). Flora of Eastern Karnataka (Vol. 1). Mittal Publications.
Sirot, V., Samieri, C., Volatier, L. and Leblanc, C. (2008). Cadmium dietary intake and biomarker data in French high seafood consumers. Exposed Science and Environmental Epidemiology, 18(4), 400–409.
Varshney, R. and Kale, R. K. (1990). Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. International Journal of Radiation and Biology, 58(5), 733–743.
Weber, E. (2017). Invasive plant species of the world: a reference guide to environmental weeds. Cabi.
Winiarska-Mieczan A. (2015). The potential protective effect of green, black, red and white tea infusions against adverse effect of cadmium and lead during chronic exposure- A rat model study. Regulatory Toxicology and Pharmacology, 73(2), 521-529
Wongmekiat, O., Peerapanyasut, W. and Kobroob, A. (2018). Catechin supplementation prevents kidney damage in rats repeatedly exposed to cadmium through mitochondrial protection. Naunyn-Schmiedeberg's Archives of Pharmacology, 391 (4), 385-394.
Wu, H., Liao, Q., Chillrud, S.N., Yang, Q., Huang, L., Bi, J. and Yan, B. (2016). Environmental Exposure to Cadmium: Health Risk Assessment and its Associations with Hypertension and Impaired Kidney Function. Scientific Report, 6 (1), 1-9
Yanchun, Z., Xue, J., Firdous, S. M. and Xue, W. (2021). Protective Effect of Ipomoea staphylina against Cadmium-Induced Cardiotoxicity in Wistar Rats. Indian Journal of Pharmaceutical Sciences, 83(1), 93-100
How to Cite
Copyright (c) 2022 Omotayo Ilesanmi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.